Journal article
Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer
LH Porter, MG Lawrence, H Wang, AK Clark, A Bakshi, D Obinata, D Goode, M Papargiris, undefined Mural, D Clouston, A Ryan, S Norden, E Corey, PS Nelson, JT Isaacs, J Grummet, J Kourambas, S Sandhu, DG Murphy, D Pook Show all
Prostate | WILEY | Published : 2019
DOI: 10.1002/pros.23839
Abstract
Background: Serially transplantable patient-derived xenografts (PDXs) are invaluable preclinical models for studying tumor biology and evaluating therapeutic agents. As these models are challenging to establish from prostate cancer specimens, the ability to preserve them through cryopreservation has several advantages for ongoing research. Despite this, there is still uncertainty about the ability to cryopreserve PDXs of prostate cancer. This study compared three different cryopreservation protocols to identify a method that can be used to reproducibly cryopreserve a diverse cohort of prostate cancer PDX models. Methods: One serially transplantable prostate cancer PDX from the Melbourne Urol..
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Grants
Awarded by National Institutes of Health
Funding Acknowledgements
Endocrine Society of Australia, Grant/Award Number: Research Seed Grant; Victorian Cancer Agency, Grant/Award Numbers: MCRF15023, MCRF18017, CAPTIV; Faculty of Medicine, Nursing and Health Sciences, Monash University, Grant/Award Number: Bridging Post-doctoral Fellowship; Peter and Lyndy White Foundation; EJ Whitten Foundation; TissuPath Pathology; Movember Foundation, Grant/Award Number: Global Action Plan 1; Congressionally Directed Medical Research Programs, Grant/Award Numbers: W81XWH1810348, W81XWH1810349, W81XWH1810347; National Health and Medical Research Council, Grant/Award Numbers: 1059855, 1138242, 1156570, 1002648, 1077799, 1140222